Alovudine

Modify Date: 2024-01-06 18:07:22

Alovudine Structure
Alovudine structure
Common Name Alovudine
CAS Number 25526-93-6 Molecular Weight 244.22
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C10H13FN2O4 Melting Point 176-178ºC(lit.)
MSDS N/A Flash Point N/A

 Use of Alovudine


3'-Fluoro-3'-deoxythymidine (Alovudine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer[1].

 Names

Name 3'-Deoxy-3'-fluorothymidine
Synonym More Synonyms

 Alovudine Biological Activity

Description 3'-Fluoro-3'-deoxythymidine (Alovudine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer[1].
Related Catalog
References

[1]. Challapalli A, et al. 3'-Deoxy-3'-18F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer. Eur J Nucl Med Mol Imaging. 2015 May;42(6):831-40.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 176-178ºC(lit.)
Molecular Formula C10H13FN2O4
Molecular Weight 244.22
Exact Mass 244.085938
PSA 84.32000
LogP -0.52
Index of Refraction 1.565

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XP2073000
CHEMICAL NAME :
Thymidine, 3'-deoxy-3'-fluoro-
CAS REGISTRY NUMBER :
25526-93-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-F-N2-O4
MOLECULAR WEIGHT :
244.25
WISWESSER LINE NOTATION :
T6NVMVJ E1 A- ET5OTJ B1Q CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
10 umol/L
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 32,178,1977

 Synthetic Route

 Synonyms

MFCD00056058
3,-Deoxy-3,-fluoro Thymidine
Thymidine, 3'-deoxy-3'-fluoro-
Alovudine