Cbl-b-IN-3

Modify Date: 2024-08-29 19:51:45

Cbl-b-IN-3 Structure
Cbl-b-IN-3 structure
Common Name Cbl-b-IN-3
CAS Number 2573775-59-2 Molecular Weight 537.62
Density N/A Boiling Point N/A
Molecular Formula C30H34F3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cbl-b-IN-3


Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].

 Names

Name Cbl-b-IN-3

 Cbl-b-IN-3 Biological Activity

Description Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].
Related Catalog
Target

IC50: < 1 nM (Cbl-b)[1]

In Vitro Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody[1].
References

[1]. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.

 Chemical & Physical Properties

Molecular Formula C30H34F3N5O
Molecular Weight 537.62