15-Acetoxyscirpenol

Modify Date: 2024-01-04 18:01:57

15-Acetoxyscirpenol structure	Common Name	15-Acetoxyscirpenol
	CAS Number	2623-22-5	Molecular Weight	324.36900
	Density	1.34g/cm3	Boiling Point	465.5ºC at 760mmHg
	Molecular Formula	C₁₇H₂₄O₅	Melting Point	170-172 °C
	MSDS	N/A	Flash Point	167.3ºC

Use of 15-Acetoxyscirpenol

15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3[1].

Name	Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate
Synonym	More Synonyms

Description	15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Others Signaling Pathways >> Apoptosis >> Caspase
Target	Caspase
References	[1]. Lee DH, et al. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54.

Density	1.34g/cm3
Boiling Point	465.5ºC at 760mmHg
Melting Point	170-172 °C
Molecular Formula	C₁₇H₂₄O₅
Molecular Weight	324.36900
Flash Point	167.3ºC
Exact Mass	324.15700
PSA	88.52000
LogP	0.55410
Vapour Pressure	1.27E-10mmHg at 25°C
Index of Refraction	1.584
Storage condition	-20°C

15-Acetoxyscirpenol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0111000

CHEMICAL NAME :: Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15-acetate

CAS REGISTRY NUMBER :: 2623-22-5

LAST UPDATED :: 198709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H24-O6

MOLECULAR WEIGHT :: 324.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 725 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

Hazard Codes	T+
Risk Phrases	R25
RIDADR	UN 2811 6.1/PG 3
Packaging Group	II
Hazard Class	6.1(a)

Diacetoxyscirpenol

CAS#:2270-40-8

~64%

15-Acetoxyscirpenol

CAS#:2623-22-5

Literature: Richardson, Stewart K.; Jeganathan, Alwarsamy; Mani, Rajarathnam S.; Haley, Boyd E.; Watt, David S.; Trusal, Lynn R. Tetrahedron, 1987 , vol. 43, # 13 p. 2925 - 2934

Diacetoxyscirpenol

CAS#:2270-40-8

15-Acetoxyscirpenol

CAS#:2623-22-5

Trichothec-9-en...

CAS#:2270-41-9

Literature: Desjardins, Anne E.; McCormick, Susan P.; Appell, Michael Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 16 p. 6487 - 6492

Precursor 1
CAS#:2270-40-8 Diacetoxyscirpenol
DownStream 0

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 15-Acetoxyscirpenol
Price: Click To Check
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 15-Acetoxyscirpen-3,4-diol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Trichothec-9-ene-3,4,15-triol,12,13-epoxy-, 15-acetate, (3a,4b)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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