AG 045572

Modify Date: 2024-02-26 13:24:26

AG 045572 Structure
AG 045572 structure
Common Name AG 045572
CAS Number 263847-55-8 Molecular Weight 491.62
Density N/A Boiling Point N/A
Molecular Formula C30H37NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AG 045572


AG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone[1].

 Names

Name 5-[(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide
Synonym More Synonyms

 AG 045572 Biological Activity

Description AG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone[1].
Related Catalog
References

[1]. Iatsimirskaia EA, et al. Effect of testosterone suppression on the pharmacokinetics of a potent gnRH receptor antagonist. Pharm Res. 2002 Feb;19(2):202-8.  

 Chemical & Physical Properties

Molecular Formula C30H37NO5
Molecular Weight 491.62
Exact Mass 491.26700
PSA 69.93000
LogP 6.87890

 Synonyms

Ambenonium dichloride
Furan-1
CMPD-1
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