1,4-(2H6)Naphthalenedione

Modify Date: 2024-01-12 01:04:11

1,4-(2H6)Naphthalenedione structure	Common Name	1,4-(2H6)Naphthalenedione
	CAS Number	26473-08-5	Molecular Weight	164.190
	Density	1.3±0.1 g/cm3	Boiling Point	297.9±40.0 °C at 760 mmHg
	Molecular Formula	C₁₀D₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	111.2±24.3 °C

Use of 1,4-(2H6)Naphthalenedione

1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

Name	1,4-naphthoquinone-d6
Synonym	More Synonyms

Description	1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Coelho-Cerqueira E, et al. Beyond topoisomerase inhibition: antitumor 1,4-naphthoquinones as potential inhibitors of human monoamine oxidase. Chem Biol Drug Des. 2014 Apr;83(4):401-10.

Density	1.3±0.1 g/cm3
Boiling Point	297.9±40.0 °C at 760 mmHg
Molecular Formula	C₁₀D₆O₂
Molecular Weight	164.190
Flash Point	111.2±24.3 °C
Exact Mass	164.074432
PSA	34.14000
LogP	1.79
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.617

(2H8)Naphthalene

CAS#:1146-65-2

2-naphthol-d8

CAS#:78832-61-8

1,4-(2H6)Naphth...

CAS#:26473-08-5

Literature: Barkanova; Kaliya; Luk'yanets Mendeleev Communications, 2001 , vol. 11, # 3 p. 116 - 118

Precursor 1
CAS#:1146-65-2 (2H8)Naphthalene
DownStream 0

Hexadeuterio-1,4-naphthoquinone

2.3-dicyano-1,4-naphtho-quinone

2,3-dicyano-1,4-napthoquinone

2,3-dicyanonaphtho-1,4-quinone

Hexadeuteronaphtha-1,4-chinon

1,4-dioxo-1,4-dihydronaphthalene-2,3-dicarbonitrile

1,4<D6>-Naphthochinon

(H)Naphthalene-1,4-dione

1,4-(H)Naphthalenedione

1,4-Naphthalenedione-d

1,4-naphthoquinone-2,3-dicarbonitrile

<D6>-1,4-Naphthochinon

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1,4-Naphthoquinone-d6
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Purity: 98.0%
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