Endovion

Modify Date: 2024-01-10 19:01:15

Endovion Structure
Endovion structure
Common Name Endovion
CAS Number 265646-85-3 Molecular Weight 495.18
Density N/A Boiling Point N/A
Molecular Formula C16H9BrF6N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Endovion


Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].

 Names

Name 1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-tetrazol-5-yl)phenyl]urea
Synonym More Synonyms

 Endovion Biological Activity

Description Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].
Related Catalog
Target

Chloride channel, VRAC/VSOAC[1]. ANO1[2].

References

[1]. Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73.

[2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.

 Chemical & Physical Properties

Molecular Formula C16H9BrF6N6O
Molecular Weight 495.18
Exact Mass 493.99300
PSA 99.08000
LogP 5.39740
Storage condition 2-8℃

 Synonyms

Urea,N-(3,5-bis(trifluoromethyl)phenyl)-N'-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)
UNII-943YH53W21
NS 3728