LY43578

Modify Date: 2024-02-05 23:03:38

LY43578 structure	Common Name	LY43578
	CAS Number	26766-35-8	Molecular Weight	331.20
	Density	1.376g/cm3	Boiling Point	494.9ºC at 760mmHg
	Molecular Formula	C₁₇H₁₂Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	253.1ºC

Use of LY43578

LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].

Name	bis(4-chlorophenyl)-pyrimidin-5-ylmethanol
Synonym	More Synonyms

Description	LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
References	[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604. [2]. Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

References

[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604.

[2]. Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186.

Density	1.376g/cm3
Boiling Point	494.9ºC at 760mmHg
Molecular Formula	C₁₇H₁₂Cl₂N₂O
Molecular Weight	331.20
Flash Point	253.1ºC
Exact Mass	330.03300
PSA	46.01000
LogP	4.06760
Vapour Pressure	1.31E-10mmHg at 25°C
Index of Refraction	1.643

5-Bromopyrimidine

CAS#:4595-59-9

4,4'-Dichlorobe...

CAS#:90-98-2

~53%

LY43578

CAS#:26766-35-8

Literature: Taylor, Harold M.; Jones, C. David; Davenport, James D.; Hirsch, Kenneth S.; Kress, T.J.; Weaver, Dix Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1359 - 1365

Precursor 2
CAS#:4595-59-9 5-Bromopyrimidine CAS#:90-98-2 4,4'-Dichlorobe...
DownStream 4
CAS#:26766-37-0 LY56110 CAS#:108395-11-5 5-[bis(4-chloro... CAS#:108395-10-4 5-[bis(4-chloro... CAS#:102993-90-8 5-[bis(4-chloro...

bis(4-chlorophenyl)(pyrimidin-5-yl) methanol

Bis(4-chlorophenyl)(5-pyrimidinyl)methanol

LY43578

Use of LY43578

Names

LY43578 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms