Oxysophocarpine

Modify Date: 2024-01-02 08:38:40

Oxysophocarpine Structure
Oxysophocarpine structure
Common Name Oxysophocarpine
CAS Number 26904-64-3 Molecular Weight 262.347
Density N/A Boiling Point N/A
Molecular Formula C15H22N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Oxysophocarpine


Oxysophocarpine is an alkaloid extracted from Siphocampylus verticillatus. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems[1]. Oxysophocarpine inhibits the growth and metastasis of  oral squamous cell carcinoma (OSCC)[2].

 Names

Name oxysophocarpine
Synonym More Synonyms

 Oxysophocarpine Biological Activity

Description Oxysophocarpine is an alkaloid extracted from Siphocampylus verticillatus. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems[1]. Oxysophocarpine inhibits the growth and metastasis of  oral squamous cell carcinoma (OSCC)[2].
Related Catalog
In Vitro Oxysophocarpine (5 μM) inhibits proliferation and reduces migration and invasion of SCC-9 and SCC-15 oral squamous cell carcinoma (OSCC) cells in vitro[1].
References

[1]. Xu T, et al. Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice.Mol Med Rep. 2013 Jun;7(6):1819-25.

[2]. Liu, R., Peng, J., Wang, H., et al. Oxysophocarpine retards the growth and metastasis of oral squamous cell carcinoma by targeting the Nrf2/HO-1 axis. Cell Physiol. Biochem. 49(5), 1717-1733 (2018).

 Chemical & Physical Properties

Molecular Formula C15H22N2O2
Molecular Weight 262.347
Exact Mass 262.168121
PSA 49.74000
LogP -0.41

 Synthetic Route

~66%

Oxysophocarpine Structure

Oxysophocarpine

CAS#:26904-64-3

Literature: CSPC Zongqi Pharmaceutical Technology (Shijiahuang) Co., Ltd.; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences; Jiang, Jiandong; Song, Danqing; Du, Nana; Peng, Zonggen; Wang, Yuping; Gao, Limei; Han, Yanxing; Li, Xin; Li, Chunxin Patent: US2013/190345 A1, 2013 ; Location in patent: Paragraph 0619 ;

 Precursor & DownStream

Precursor  1

DownStream  1

 Synonyms

N-oxosophocarpine
sophocarpidine
(7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-Decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide
Oxysophocarpine
1-oxy-13,14-didehydro-matridin-15-one
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, 4-oxide, (7aS,13aR,13bR,13cS)-
Matridin-15-one, 13,14-didehydro-, 1-oxide
(4R,7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-Decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-
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