Oxametacin

Modify Date: 2024-01-06 16:01:33

Oxametacin Structure
Oxametacin structure
 Common Name Oxametacin
CAS Number 27035-30-9 Molecular Weight 372.80200
Density 1.35g/cm3 Boiling Point N/A
Molecular Formula C19H17ClN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Oxametacin


Oxametacin is a anti-inflammatory compound used with care in anticoagulated patients. It has analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin.

 Names

Name oxametacin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.35g/cm3
Molecular Formula C19H17ClN2O4
Molecular Weight 372.80200
Exact Mass 372.08800
PSA 80.56000
LogP 3.73900
Index of Refraction 1.63

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NL3668500
CHEMICAL NAME :
Indole-3-acetohydroxamic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
CAS REGISTRY NUMBER :
27035-30-9
BEILSTEIN REFERENCE NO. :
0497721
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H17-Cl-N2-O4
MOLECULAR WEIGHT :
372.83
WISWESSER LINE NOTATION :
T56 BNJ BVR DG& C1 D1VMQ GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
78 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
92 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,319,1975

 Safety Information

HS Code 2933990090

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Oxametacinum [INN-Latin]
Oxametacine [INN-French]
Oxametacin
2-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-indol-3-yl]-N-hydroxy-acetamide
Oxametacin [INN]
Acido indoxamico [Italian]
Indoxamic acid
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-hydroxyacetamide
Oxametacine
2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}ethanehydroxamic acid
Oxametacina [INN-Spanish]
1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetohydroxamic acid
Oxamethacin
1-(p-chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetohydroxamic acid
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