Cystamine-d8 (dihydrochloride)

Modify Date: 2024-01-11 16:20:37

Cystamine-d8 (dihydrochloride) Structure
Cystamine-d8 (dihydrochloride) structure
Common Name Cystamine-d8 (dihydrochloride)
CAS Number 2712126-51-5 Molecular Weight 196.79
Density N/A Boiling Point N/A
Molecular Formula C4H5D8ClN2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cystamine-d8 (dihydrochloride)


Cystamine-d8 (dihydrochloride) is the deuterium labeled Cystamine (dihydrochloride)[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

 Names

Name Cystamine-d8 (dihydrochloride)

 Cystamine-d8 (dihydrochloride) Biological Activity

Description Cystamine-d8 (dihydrochloride) is the deuterium labeled Cystamine (dihydrochloride)[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Mathieu Lesort, et al. Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem. 2003 Feb 7;278(6):3825-30.  

[3]. Alpaslan Dedeoglu, et al. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002 Oct 1522(20):8942-50.  

[4]. Thomas M Jeitner, et al. Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo. Biosci Rep. 2018 Sep 538(5):BSR20180691.  

 Chemical & Physical Properties

Molecular Formula C4H5D8ClN2S2
Molecular Weight 196.79