N-Methyl-dosimertinib-d5

Modify Date: 2024-04-09 13:26:15

N-Methyl-dosimertinib-d5 structure	Common Name	N-Methyl-dosimertinib-d5
	CAS Number	2719690-98-7	Molecular Weight	433.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₉D₅N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-Methyl-dosimertinib-d5

N-Methyl-dosimertinib-d5 is the deuterium labeled of Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].

Name	N-Methyl-dosimertinib-d5

Description	N-Methyl-dosimertinib-d5 is the deuterium labeled of Dosimertinib (HY-142283). Dosimertinib is a highly potent, selective, and orally active deuterated EGFR inhibiotor. Dosimertinib can be used for the research of non-small-cell lung cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937.

Molecular Formula	C₂₄H₁₉D₅N₆O₂
Molecular Weight	433.52

N-Methyl-dosimertinib-d5

Use of N-Methyl-dosimertinib-d5

Names

N-Methyl-dosimertinib-d5 Biological Activity

Chemical & Physical Properties