W1131

Modify Date: 2024-01-08 23:11:59

W1131 Structure
W1131 structure
Common Name W1131
CAS Number 2740522-79-4 Molecular Weight 429.43
Density N/A Boiling Point N/A
Molecular Formula C23H19N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of W1131


W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway[1].

 Names

Name W1131

 W1131 Biological Activity

Description W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway[1].
Related Catalog
In Vitro W1131(0-2 μM;72 h)抑制胃癌 AGS 细胞的存活、迁移和侵袭,并在处理 3 天后,抑制集落形成[1]。 W1131(0.1-3 μM;24 小时)有效抑制 AGS 细胞中 STAT3 的磷酸化[1]。 W1131(1 μM;48 小时)触发铁死亡并抑制胃癌中 GPX4、SLC7A11 和 FTH1 的表达[1]。 Western Blot Analysis[1] Cell Line: AGS cells Concentration: 0.1 μM, 0.3 μM, 1 μM, and 3 μM Incubation Time: 24 hours Result: Dose-dependently decreased the phosphorylated Y705-STAT3, but not STAT5, JAK2, and AKT. Immunofluorescence[1] Cell Line: AGS cells Concentration: 0.3 μM, 1 μM Incubation Time: 12 hours Result: Significantly promoted lipid ROS formation, and induced Fe2+ accumulation.
In Vivo W1131(3 mg/kg,10 mg/kg;腹腔注射;每天一次,持续 2 周)以剂量依赖性方式抑制肿瘤生长,并在 BALB/c-nu/nu 小鼠的 MGC803 皮下异种移植模型中诱导铁死亡[1] 。 Animal Model: MGC803 subcutaneous xenografts in mouse[1] Dosage: 3 mg/kg, 10 mg/kg Administration: Intraperitoneal injection; once daily for 2 weeks Result: Inhibited GPX4, SLC7A11, and FTH1 expression level, indicating the induction of ferroptosis. Caused insignificant change of body weight.
References

[1]. Ouyang S, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022 Jun;52:102317.  

 Chemical & Physical Properties

Molecular Formula C23H19N5O4
Molecular Weight 429.43