AChE/BuChE-IN-3
Modify Date: 2024-04-10 17:48:38
AChE/BuChE-IN-3 structure
|
Common Name | AChE/BuChE-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 2742707-47-5 | Molecular Weight | 585.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H30F3N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AChE/BuChE-IN-3AChE/BuChE-IN-3 (compound C4) is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1]. |
| Name | AChE/BuChE-IN-3 |
|---|
| Description | AChE/BuChE-IN-3 (compound C4) is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 5.77 μM (BuChE), 0.65 μM (AChE)[1] |
| In Vitro | AChE/BuChE-IN-3 (compound C4) (12.5-100 μM; 48 hours) exhibits no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increases cell viabilities[1]. Cell Viability Assay Cell Line: SH-SY5Y[1] Concentration: 12.5 μM, 25 μM, 50 μM and 100 μM Incubation Time: 48 hours Result: Exhibited no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increased cell viabilities. |
| References |
| Molecular Formula | C30H30F3N3O6 |
|---|---|
| Molecular Weight | 585.57 |