ARV-766

Modify Date: 2024-08-01 19:55:50

ARV-766 Structure
ARV-766 structure
Common Name ARV-766
CAS Number 2750830-09-0 Molecular Weight 807.95
Density N/A Boiling Point N/A
Molecular Formula C45H54FN7O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ARV-766


ARV-766 is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations[1].

 Names

Name ARV-766

 ARV-766 Biological Activity

Description ARV-766 is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations[1].
Related Catalog
References

[1]. Petrylak D P, et al. A phase 2 expansion study of ARV-766, a PROTAC androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC)[J]. 2023.

 Chemical & Physical Properties

Molecular Formula C45H54FN7O6
Molecular Weight 807.95