Sandacanol

Modify Date: 2024-01-04 09:52:40

Sandacanol Structure
Sandacanol structure
Common Name Sandacanol
CAS Number 28219-61-6 Molecular Weight 208.340
Density 0.9±0.1 g/cm3 Boiling Point 287.4±9.0 °C at 760 mmHg
Molecular Formula C14H24O Melting Point N/A
MSDS N/A Flash Point 103.5±15.0 °C

 Use of Sandacanol


Sandacanol is a specific agonist of olfactory receptor (OR10H1). Sandacanol induces cell cycle arrest and some apoptosis in bladder cancer cells[1].

 Names

Name 2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol
Synonym More Synonyms

 Sandacanol Biological Activity

Description Sandacanol is a specific agonist of olfactory receptor (OR10H1). Sandacanol induces cell cycle arrest and some apoptosis in bladder cancer cells[1].
Related Catalog
In Vitro Sandacanol (50, 100, 300, 500, and 700 μM; 24 or 48 h) treatment significantly diminishes cell viability, cell proliferation and migration and induces a limited degree of apoptosis in BFTC905 bladder cancer cells[1].
References

[1]. Lea Weber, et al. Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer. Front Physiol. 2018 May 16;9:456.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 287.4±9.0 °C at 760 mmHg
Molecular Formula C14H24O
Molecular Weight 208.340
Flash Point 103.5±15.0 °C
Exact Mass 208.182709
PSA 20.23000
LogP 4.97
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.478
Storage condition -20°C
Water Solubility INSOLUBLE

 MSDS

Name: 2-Ethyl-4-(2 2 3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol mixture Material Safety Data Sheet
Synonym: 2-But-2-en-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3- cyclopenten-1-yl)
CAS: 28219-61-6
Section 1 - Chemical Product MSDS Name:2-Ethyl-4-(2 2 3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol mixture Material Safety Data Sheet
Synonym:2-But-2-en-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3- cyclopenten-1-yl)

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
28219-61-6 2-Ethyl-4-(2,2,3-trimethylcyclopent-3- 96 248-908-8
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
This material is lighter than water and insoluble in water. The fire could easily be spread by the use of water in an area where the water cannot be contained. Use agent most appropriate to extinguish fire.
Use dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 28219-61-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: colorless to pale yellow
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 114 - 116 deg C @ 1mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: > 100 deg C (> 212.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: .9160g/cm3
Molecular Formula: C14H24O
Molecular Weight: 208.1674

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 28219-61-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 28219-61-6: No information available.
Canada
CAS# 28219-61-6 is listed on Canada's DSL List.
CAS# 28219-61-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 28219-61-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Safety Phrases S24/25
HS Code 3307410000

 Customs

HS Code 3307410000

 Synonyms

Levosandol
BAGDANOL
MFCD00067059
Bacdanol
Sandolen
Sandal fleur
Bacdanol [IFF]
Sandacanol
Balinol
Sandranol [Dragoco]
2-Buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-, (2E)-
Sandrolene
EINECS 248-908-8
2-Ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Bangalol
SANDENOL 208
Sandolene
2-Buten-1-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
SANDEROL 208
(2E)-2-Ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Sandalrome
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