Beta-Elemonic acid

Modify Date: 2024-01-07 19:39:32

Beta-Elemonic acid structure	Common Name	Beta-Elemonic acid
	CAS Number	28282-25-9	Molecular Weight	454.684
	Density	1.07	Boiling Point	565.2±50.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₆O₃	Melting Point	216-219 ºC
	MSDS	Chinese USA	Flash Point	309.6±26.6 °C

Use of Beta-Elemonic acid

β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].

Name	β-Elemonic acid
Synonym	More Synonyms

Description	β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2
In Vitro	β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner[1]. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 µM[1]. β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase[1]. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells[1].
References	[1]. Atta-ur-Rahman, et al. Bioactive constituents from Boswellia papyrifera. J Nat Prod. 2005 Feb;68(2):189-93. [2]. Wu TT, et al. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The roleof MAPK, ROS activation and glutathione depletion. Oncol Rep. 2016 Jan;35(1):227-34.

Density	1.07
Boiling Point	565.2±50.0 °C at 760 mmHg
Melting Point	216-219 ºC
Molecular Formula	C₃₀H₄₆O₃
Molecular Weight	454.684
Flash Point	309.6±26.6 °C
Exact Mass	454.344696
PSA	54.37000
LogP	8.56
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.542
Storage condition	-20℃

RIDADR	NONH for all modes of transport

(2S)-2-[(3R,5R,...

CAS#:82509-40-8

Beta-Elemonic acid

CAS#:28282-25-9

Literature: Ruzicka et al. Helvetica Chimica Acta, 1943 , vol. 26, p. 1659,1664

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beta-Elemonic acid

Shanghai Nianxing Industrial Co., Ltd
China
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Purity: 98.0%
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Beta-Elemonic acid

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