Acetyl-Pepstatin

Modify Date: 2024-01-02 13:45:22

Acetyl-Pepstatin structure	Common Name	Acetyl-Pepstatin
	CAS Number	28575-34-0	Molecular Weight	643.812
	Density	1.1±0.1 g/cm3	Boiling Point	992.8±65.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₅₇N₅O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	554.2±34.3 °C

Use of Acetyl-Pepstatin

Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease[1][2].

Name	(3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid
Synonym	More Synonyms

Description	Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease)[1]
In Vitro	Pepstatin (Pepstatin A) (7 μM; 48 h) affects the intracellular processing of HIV-specific gag protein[2].
In Vivo	Pepstatin (Pepstatin A) has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route[1]. Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats[1]. Animal Model: Pylorus ligated male Wistar rats[1] Dosage: 0.5, 1, 10 and 50 mg/kg Administration: Oral administration, 15 minutes after pyloric ligation Result: Effectively prevented stomach ulceration.

Density	1.1±0.1 g/cm3
Boiling Point	992.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₅₇N₅O₉
Molecular Weight	643.812
Flash Point	554.2±34.3 °C
Exact Mass	643.415649
PSA	223.26000
LogP	0.75
Appearance of Characters	Solid \| White to Off-white
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.508
Storage condition	−20°C

Acetyl-Pepstatin MSDS(Chinese)

Hazard Codes	Xi
WGK Germany	3

Pepstatin Ac

N-Acetyl Pepstatin

5hvp

Ac-Val-Val-Sta-Ala-Sta

N-Acetyl-L-valyl-N-[(3S,4S)-1-{[(2S)-1-{[(2S,3S)-1-carboxy-2-hydroxy-5-methyl-3-hexanyl]amino}-1-oxo-2-propanyl]amino}-3-hydroxy-6-methyl-1-oxo-4-heptanyl]-L-valinamide

Acetyl-pepstatin

Pepsidine C

Pepsidin C

L-Valinamide, N-acetyl-L-valyl-N-[(1S,2S)-4-[[(1S)-2-[[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-

Acetylpepstatin

Ac-Pepstatin

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Acetyl-Pepstatin
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: Ac-Pepstatin
Price: $Inquiry/1kg
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: Acetyl-Pepstatin
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

Get all suppliers and price by the below link:

Acetyl-Pepstatin suppliers

Acetyl-Pepstatin price

Acetyl-Pepstatin

Use of Acetyl-Pepstatin

Names

Acetyl-Pepstatin Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms