4',6-Diamidino-2-phenylindole dihydrochloride structure
|
Common Name | 4',6-Diamidino-2-phenylindole dihydrochloride | ||
---|---|---|---|---|
CAS Number | 28718-90-3 | Molecular Weight | 350.246 | |
Density | 1.41g/cm3 | Boiling Point | 545.4ºC at 760mmHg | |
Molecular Formula | C16H17Cl2N5 | Melting Point | >300°C (dec.) | |
MSDS | USA | Flash Point | 283.6ºC |
Use of 4',6-Diamidino-2-phenylindole dihydrochlorideDAPI dihydrochloride (4',6-diamidino-2-phenylindole) is a fluorescent stain by binding in the minor grove of A-T rich sequences of DNA. |
Name | 2-(4-carbamimidoylphenyl)-1H-indole-6-carboximidamide,dihydrochloride |
---|---|
Synonym | More Synonyms |
Description | DAPI dihydrochloride (4',6-diamidino-2-phenylindole) is a fluorescent stain by binding in the minor grove of A-T rich sequences of DNA. |
---|---|
Related Catalog | |
In Vitro | DAPI (4',6-diamidino-2-phenylindole) is a DNA-specific probe which forms a fluorescent complex by attaching in the minor grove of A-T rich sequences of DNA. It also forms nonfluorescent intercalative complexes with double-stranded nucleic acids. DAPI can be used as a DNA-specific probe for flow cytometry, chromosome staining, DNA visualization and quantitation in histochemistry and biochemistry[1]. |
References |
Density | 1.41g/cm3 |
---|---|
Boiling Point | 545.4ºC at 760mmHg |
Melting Point | >300°C (dec.) |
Molecular Formula | C16H17Cl2N5 |
Molecular Weight | 350.246 |
Flash Point | 283.6ºC |
Exact Mass | 349.086090 |
PSA | 115.53000 |
LogP | 5.60710 |
Vapour Pressure | 5.96E-12mmHg at 25°C |
Storage condition | −20°C |
Water Solubility | H2O: 10 mg/mL heat or sonication may be required. Solutions stored in the dark at room temperature or 4 °C should be stable for 2 to 3 weeks. |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
Hazard Codes | Xi: Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36-S24/25-S22 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | NL5995050 |
HS Code | 2933990090 |
HS Code | 2933990090 |
---|---|
Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
Biomaterials 51 , 1-11, (2015) Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer c... |
|
Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells.
J. Pineal Res. 58(3) , 310-20, (2015) Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In... |
|
The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
Drug Des. Devel. Ther. 9 , 1627-52, (2015) Alisertib (ALS) is an investigational potent Aurora A kinase inhibitor currently undergoing clinical trials for the treatment of hematological and non-hematological malignancies. However, its antitumo... |
2-(4-Amidinophenyl)indole-6-carboxamidine Dihydrochloride |
EINECS 249-186-7 |
DAPI hydrochloride |
2-(4-Carbamimidoylphenyl)-1H-indole-6-carboximidamide dihydrochloride |
MFCD00012681 |
2-(4-Amidinophenyl) |
1H-Indole-6-carboximidamide, 2-[4-(aminoiminomethyl)phenyl]-, hydrochloride (1:2) |
4′,6′-Diamidino-2-phenylindole dihydrochloride |
2-(4-Carbamimidoylphenyl)indole-6-carboximidamide Dihydrochloride |
4',6-diamidine-2-phenylindole dihydrochloride |
DAPI,Dihydrochloride |
4,6-Diamidino-2-Phenylindole Dihydrochloride |
DAPI dihydrochloride |
4',6-Diamidino-2-phenylindole Dihydrochloride |
2-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride |