Ethynodiol diacetate

Modify Date: 2024-01-02 14:27:36

Ethynodiol diacetate Structure
Ethynodiol diacetate structure
Common Name Ethynodiol diacetate
CAS Number 297-76-7 Molecular Weight 384.509
Density 1.1±0.1 g/cm3 Boiling Point 461.1±45.0 °C at 760 mmHg
Molecular Formula C24H32O4 Melting Point 128 - 131ºC
MSDS Chinese USA Flash Point 221.8±27.1 °C
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of Ethynodiol diacetate


Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.

 Names

Name ethynodiol diacetate
Synonym More Synonyms

 Ethynodiol diacetate Biological Activity

Description Ethynodiol diacetate is a steroidal progestin which is used as a hormonal contraceptive, it has relatively little or no potency as an androgen,has significant estrogenic effects.
Related Catalog

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 461.1±45.0 °C at 760 mmHg
Melting Point 128 - 131ºC
Molecular Formula C24H32O4
Molecular Weight 384.509
Flash Point 221.8±27.1 °C
Exact Mass 384.230072
PSA 52.60000
LogP 5.44
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.546

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC8963000
CHEMICAL NAME :
19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate
CAS REGISTRY NUMBER :
297-76-7
LAST UPDATED :
199510
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C24-H32-O4
MOLECULAR WEIGHT :
384.56
WISWESSER LINE NOTATION :
L E5 B666 MUTJ E1 FOV1 F1UU1 OOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
840 ug/kg
SEX/DURATION :
female 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
840 ug/kg
SEX/DURATION :
female 24 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
700 ug/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
240 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
16500 ug/kg
SEX/DURATION :
male 60 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
48 mg/kg
SEX/DURATION :
male 12 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1400 ug/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
140 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
120 ug/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1560 ug/kg
SEX/DURATION :
female 1-3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Mammal - cattle Cells - not otherwise specified
DOSE/DURATION :
10 mg/L
REFERENCE :
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 120,390,1974 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,387,1979

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H312-H332-H351
Precautionary Statements P280
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 22-36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS RC8963000

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 Synonyms

Metrodiol diacetate
Ethinodiol diacetate
Ovulen
Continuin
Metrodiol
Estr-4-ene-3,17-diol, 17-ethynyl-, diacetate
Femulen
Cervicundin
ETHYNODIOL DIACETATE
MFCD00083326
3β,17β-Diacetoxy-17α-ethynyl-4-estrene
EINECS 206-044-9
19-Norpregn-4-en-20-yne-3,17-diyl diacetate
17a-Ethynyl-4-estren-3b,17-diol diacetate
[(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
Luto-metrodiol
Ovulen 50
Ethynodiol (diacetate)
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