NPS ALX Compound 4a

Modify Date: 2024-01-14 12:33:51

NPS ALX Compound 4a Structure
NPS ALX Compound 4a structure
Common Name NPS ALX Compound 4a
CAS Number 299433-10-6 Molecular Weight 431.55
Density N/A Boiling Point N/A
Molecular Formula C25H25N3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NPS ALX Compound 4a


NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM[1].

 Names

Name NPS ALX Compound 4a dihydrochloride,6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride
Synonym More Synonyms

 NPS ALX Compound 4a Biological Activity

Description NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM[1].
Related Catalog
Target

IC50: 7.2 nM (5-HT6 receptor) Ki: 0.2 nM (5-HT6 receptor)

References

[1]. Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1719-21.

 Chemical & Physical Properties

Molecular Formula C25H25N3O2S
Molecular Weight 431.55
Exact Mass 503.12000
PSA 53.93000
LogP 7.00360

 Synonyms

Cyanopindolol hemifumarate