SKF 77434 hydrobromide

Modify Date: 2024-01-12 17:21:31

SKF 77434 hydrobromide Structure
SKF 77434 hydrobromide structure
Common Name SKF 77434 hydrobromide
CAS Number 300561-58-4 Molecular Weight 376.29
Density N/A Boiling Point N/A
Molecular Formula C19H22BrNO2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of SKF 77434 hydrobromide


SKF 77434 hydrobromide is a selective dopamine D1 receptor partial agonist. SKF 77434 hydrobromide has the potential to study cocaine addiction[1].

 Names

Name 5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol,hydrobromide
Synonym More Synonyms

 SKF 77434 hydrobromide Biological Activity

Description SKF 77434 hydrobromide is a selective dopamine D1 receptor partial agonist. SKF 77434 hydrobromide has the potential to study cocaine addiction[1].
Related Catalog
References

[1]. Cohen C, et al. Effects of D1 dopamine receptor agonists on oral ethanol self-administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology (Berl). 1999 Feb;142(1):102-10.  

 Chemical & Physical Properties

Molecular Formula C19H22BrNO2
Molecular Weight 376.29
Exact Mass 375.08300
PSA 43.70000
LogP 4.16980

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles8

More Articles
Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.

J. Neurosci. 22(22) , 9841-9, (2002)

The dynamics of dopamine receptor signaling efficacy were characterized in developing mice by measuring striatal c-Fos expression after dopaminergic agonist treatment at postnatal day 4 (P4) to P18. C...

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.

Proc. Natl. Acad. Sci. U. S. A. 96(9) , 5280-5, (1999)

To study the physiological and molecular mechanisms of age-related memory loss, we assessed spatial memory in C57BL/B6 mice from different age cohorts and then measured in vitro the late phase of hipp...

Comparison of the D1-dopamine agonists SKF-38393 and A-68930 in neonatal 6-hydroxydopamine-lesioned rats: behavioral effects and induction of c-fos-like immunoreactivity.

J. Pharmacol. Exp. Ther. 262(2) , 855-65, (1992)

Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound beha...

 Synonyms

(+/-)-7,8-Dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
Atrial natriuretic factor (1-28) (human,porcine)
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