Malformin A

Modify Date: 2024-01-12 09:02:28

Malformin A Structure
Malformin A structure
Common Name Malformin A
CAS Number 3022-92-2 Molecular Weight 529.71600
Density 1.123 g/cm3 Boiling Point 921ºC at 760 mmHg
Molecular Formula C23H39N5O5S2 Melting Point N/A
MSDS N/A Flash Point 510.8ºC

 Use of Malformin A


Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].

 Names

Name 10-butan-2-yl-7-(2-methylpropyl)-4-propan-2-yl-15,16-dithia-3,6,9,12,18-pentazabicyclo[11.4.2]nonadecane-2,5,8,11,19-pentone
Synonym More Synonyms

 Malformin A Biological Activity

Description Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9[1].
Related Catalog
References

[1]. Sun-Young Park, et al. Malformin A1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. Int J Oncol. 2017 Sep;51(3):959-966.

 Chemical & Physical Properties

Density 1.123 g/cm3
Boiling Point 921ºC at 760 mmHg
Molecular Formula C23H39N5O5S2
Molecular Weight 529.71600
Flash Point 510.8ºC
Exact Mass 529.23900
PSA 196.10000
LogP 2.21120
Index of Refraction 1.497
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON7050000
CHEMICAL NAME :
Malformin A
CAS REGISTRY NUMBER :
3022-92-2
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H39-N5-O5-S2
MOLECULAR WEIGHT :
529.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3100 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 39,1325,1975

 Safety Information

Hazard Codes T+
Risk Phrases 23/24/25
Safety Phrases 36/37/39-45

 Synonyms

Malformins
MALFORMIN A
Cyclic(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl)cyclic(1-2)-disulfide
cyclo-D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-isoleucyl
AmbotzLS-1149
Malformin A1
4-(butan-2-yl)-7-(2-methylpropyl)-10-(propan-2-yl)-15,16-dithia-2,5,8,11,19-pentaazabicyclo[11.4.2]nonadecane-3,6,9,12,18-pentone
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