(+)-Sotalol structure
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Common Name | (+)-Sotalol | ||
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CAS Number | 30236-32-9 | Molecular Weight | 272.36400 | |
Density | 1.239g/cm3 | Boiling Point | 443.3ºC at 760mmHg | |
Molecular Formula | C12H20N2O3S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 221.9ºC |
Use of (+)-Sotalol(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3]. |
Name | (+)-(s)-n-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide |
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Synonym | More Synonyms |
Description | (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3]. |
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Related Catalog | |
Target |
β-adrenoceptor |
In Vitro | (+)-Sotalol (1, 10, 100 µM) 在离体心肌中增加动作电位持续时间[2]。 (+)-Sotalol (100 μM,60 分钟) 可延长三种细胞类型 (心内膜、心外膜、心肌中部和透壁细胞) 的动作电位[4]。 |
In Vivo | (+)-Sotalol (8 mg/kg,静脉注射) 抑制程序刺激诱导的犬室性心动过速[3]。 Animal Model: Programmed stimulated Dogs[3] Dosage: 8 mg/kg Administration: Intravenous injection (i.v.) Result: Increased normal zone ventricular refractoriness, and prevented propagation of programmed ventricular extra-stimuli of sufficient prematurity to elicit tachyarrhythmias. |
References |
Density | 1.239g/cm3 |
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Boiling Point | 443.3ºC at 760mmHg |
Molecular Formula | C12H20N2O3S |
Molecular Weight | 272.36400 |
Flash Point | 221.9ºC |
Exact Mass | 272.11900 |
PSA | 86.81000 |
LogP | 2.63420 |
Index of Refraction | 1.57 |
Sotolol |
Betacotdone |
d,l-sotalol |
SORBITOL |