UNII:T875VN0D6E

Modify Date: 2024-01-09 11:38:30

UNII:T875VN0D6E structure	Common Name	UNII:T875VN0D6E
	CAS Number	303-26-4	Molecular Weight	286.80
	Density	1.2±0.1 g/cm3	Boiling Point	409.1±0.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₉ClN₂	Melting Point	65-70 °C(lit.)
	MSDS	Chinese USA	Flash Point	193.3±26.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of UNII:T875VN0D6E

1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Name	1-(4-Chlorobenzhydryl)piperazine
Synonym	More Synonyms

Description	1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >> Others
In Vitro	1-(4-氯苄基)哌嗪是美氯嗪和氯环嗪的无活性代谢物，在羟嗪和西替利嗪的商业制剂中也发现它是一种杂质。1-(4-氯苄基)哌嗪已被用于合成电压门控钠通道 1.7 (Nav1.7) 抑制剂、抗癌剂和抗组胺剂。
References	[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Density	1.2±0.1 g/cm3
Boiling Point	409.1±0.0 °C at 760 mmHg
Melting Point	65-70 °C(lit.)
Molecular Formula	C₁₇H₁₉ClN₂
Molecular Weight	286.80
Flash Point	193.3±26.5 °C
Exact Mass	286.123688
PSA	15.27000
LogP	3.44
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.592
Storage condition	Refrigerator

UNII:T875VN0D6E MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL1772000

CHEMICAL NAME :: Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-

CAS REGISTRY NUMBER :: 303-26-4

BEILSTEIN REFERENCE NO. :: 0243027

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H19-Cl-N2

MOLECULAR WEIGHT :: 286.83

WISWESSER LINE NOTATION :: T6M DNTJ DYR&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TL1772000
HS Code	2933599090

Precursor 7
CAS#:110-85-0 Piperazine CAS#:134-83-8 UNII:LC0K0NYJ2N CAS#:119-56-2 4-Chlorobenzhydrol CAS#:1155402-49-5 phenyl 4-((4-ch...
CAS#:628717-39-5 4-nitrophenyl 4... CAS#:134-85-0 4-Chlorobenzophenone CAS#:104-88-1 4-Chlorobenzaldehyde
DownStream 10
CAS#:1161573-31-4 (R)-(-)-1-[(4-c... CAS#:439858-21-6 1-[(S)-(4-Chlor... CAS#:298-55-5 Clocinizine CAS#:82-93-9 Di-Paralene
CAS#:83881-37-2 Cetirizine Amide CAS#:83881-46-3 Cetirizine meth... CAS#:2192-20-3 Hydroxyzine dih... CAS#:1104-22-9 Meclizine dihyd...
CAS#:109806-71-5 UNII:PGV947X9B1 CAS#:114624-65-6 3-[[4-[(4-chlor...

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

EINECS 206-137-4

N-(4-CHLOROBENZHYDRYL)-PIPERAZINE

Hydroxyzine Related Compound A

1-(α-Phenyl-4-chlorobenzyl)piperazine

Norchlorcyclizine

1-(4-Chlorobenzhydry)piperazine

1-((4-Chlorophenyl)(phenyl)methyl)piperazine

1-[(4-Chlorophenyl)(phenyl)methyl]piperazine

1-(4-Chlorobenzhydryl) piperazine

1-(4-Chloro-α-phenylbenzyl)piperazine

1-(p-chlorobenzhydryl)piperazine

N-[(4-chlorophenyl)phenylmethyl]piperazine

1-(4-Chlorodiphenylmethyl)piperazine

1-(4-chlorobenzhydryl)-piperazine

1-(4-chlorobenzhydryl)

Piperazine, 1- (p-chloro-α-phenylbenzyl)-

Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-

N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine

MFCD00005965

Piperazine, 1-[α-(4-chlorophenyl)benzyl]-

UNII:T875VN0D6E

4-(4-Chlorobenzhydryl)piperazine

(RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

1-[(4-chlorophenyl)phenylmethyl]-piperazine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: UNII:T875VN0D6E
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: UNII:T875VN0D6E
Price: ￥188.0/1g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Norchlorcyclizine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(4-Chlorobenzhydryl)piperazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1-(4-Chlorobenzhydryl)piperazine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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