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China
Product Name: UNII:T875VN0D6E
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Shanghai Jizhi Biochemical Technology Co., Ltd
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DC Chemicals Limited
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Product Name: Norchlorcyclizine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(4-Chlorobenzhydryl)piperazine
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1-(4-Chlorobenzhydryl)piperazine
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303-26-4

303-26-4 structure

Name: UNII:T875VN0D6E
Chemical Name: 1-(4-Chlorobenzhydryl)piperazine
CAS Number: 303-26-4
Molecular Formula: C₁₇H₁₉ClN₂
Molecular Weight: 286.80
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-07-20 07:42:55
Modify Date: 2024-01-09 11:38:30
1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Name	1-(4-Chlorobenzhydryl)piperazine
Synonyms	EINECS 206-137-4 N-(4-CHLOROBENZHYDRYL)-PIPERAZINE Hydroxyzine Related Compound A 1-(α-Phenyl-4-chlorobenzyl)piperazine Norchlorcyclizine 1-(4-Chlorobenzhydry)piperazine 1-((4-Chlorophenyl)(phenyl)methyl)piperazine 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine 1-(4-Chlorobenzhydryl) piperazine 1-(4-Chloro-α-phenylbenzyl)piperazine 1-(p-chlorobenzhydryl)piperazine N-[(4-chlorophenyl)phenylmethyl]piperazine 1-(4-Chlorodiphenylmethyl)piperazine 1-(4-chlorobenzhydryl)-piperazine 1-(4-chlorobenzhydryl) Piperazine, 1- (p-chloro-α-phenylbenzyl)- Piperazine, 1-[(4-chlorophenyl)phenylmethyl]- N-[1-(4-chlorophenyl)-1-(phenyl)methyl]piperazine MFCD00005965 Piperazine, 1-[α-(4-chlorophenyl)benzyl]- UNII:T875VN0D6E 4-(4-Chlorobenzhydryl)piperazine (RS)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 1-[(4-chlorophenyl)phenylmethyl]-piperazine

Description	1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >> Others
In Vitro	1-(4-氯苄基)哌嗪是美氯嗪和氯环嗪的无活性代谢物，在羟嗪和西替利嗪的商业制剂中也发现它是一种杂质。1-(4-氯苄基)哌嗪已被用于合成电压门控钠通道 1.7 (Nav1.7) 抑制剂、抗癌剂和抗组胺剂。
References	[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973) [2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965) [3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996) [4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014) [5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015) [6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012) [7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Density	1.2±0.1 g/cm3
Boiling Point	409.1±0.0 °C at 760 mmHg
Melting Point	65-70 °C(lit.)
Molecular Formula	C₁₇H₁₉ClN₂
Molecular Weight	286.80
Flash Point	193.3±26.5 °C
Exact Mass	286.123688
PSA	15.27000
LogP	3.44
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.592
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL1772000

CHEMICAL NAME :: Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-

CAS REGISTRY NUMBER :: 303-26-4

BEILSTEIN REFERENCE NO. :: 0243027

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H19-Cl-N2

MOLECULAR WEIGHT :: 286.83

WISWESSER LINE NOTATION :: T6M DNTJ DYR&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 12-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 147,391,1965

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TL1772000
HS Code	2933599090

Precursor 7
110-85-0 134-83-8 119-56-2 1155402-49-5
628717-39-5 134-85-0 104-88-1
DownStream 10
1161573-31-4 439858-21-6 298-55-5 82-93-9
83881-37-2 83881-46-3 2192-20-3 1104-22-9
109806-71-5 114624-65-6

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

303-26-4	130018-88-1
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1018584-77-4	91061-35-7