Spaglumic Acid

Modify Date: 2024-01-03 00:12:34

Spaglumic Acid Structure
Spaglumic Acid structure
Common Name Spaglumic Acid
CAS Number 3106-85-2 Molecular Weight 304.253
Density 1.5±0.1 g/cm3 Boiling Point 769.5±60.0 °C at 760 mmHg
Molecular Formula C11H16N2O8 Melting Point N/A
MSDS Chinese USA Flash Point 419.1±32.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Spaglumic Acid


Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.

 Names

Name n-acetyl-asp-glu
Synonym More Synonyms

 Spaglumic Acid Biological Activity

Description Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].
References

[1]. Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 769.5±60.0 °C at 760 mmHg
Molecular Formula C11H16N2O8
Molecular Weight 304.253
Flash Point 419.1±32.9 °C
Exact Mass 304.090668
PSA 170.10000
LogP -1.96
Vapour Pressure 0.0±5.7 mmHg at 25°C
Index of Refraction 1.540
Storage condition −20°C
Water Solubility H2O: 50 mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924199090

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles50

More Articles
Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus.

Neurobiol. Dis. 82 , 580-92, (2015)

Ischemic strokes cause excessive release of glutamate, leading to overactivation of N-methyl-d-aspartate receptors (NMDARs) and excitotoxicity-induced neuronal death. For this reason, inhibition of NM...

Standardized method for high-resolution 1H-NMR of cerebrospinal fluid.

Clin. Chem. 41(5) , 744-51, (1995)

This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, a...

Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

Clin. Biochem. 38(11) , 997-1008, (2005)

To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemi...

 Synonyms

N-Acetyl-L-aspartyl-L-glutamic acid
N-acetyl-1-aspartylglutamic acid
NAAGA
AC-ASP-GLU
SPAGLUMIC ACID
N-(N-Acetyl-L-a-aspartyl)-L-glutamic Acid
N-acetyl-L-aspartyl-L-glutamate
N-Acetyl-L-α-aspartyl-L-glutamic acid
isospaglumic acid
L-Glutamic acid, N-acetyl-L-α-aspartyl-
AC-ASP-GLU H2O
AC-ASP-GLU-OH
MFCD00076652
Tacrine hydrochloride
N-acetyl-aspartatylglutamate
N-(N-Acetyl-L-α-aspartyl)-L-glutamic acid
glutamic acid, N-acetylaspartyl-
ACETYL-D-E
Naaxia
NAAG
N-Acetylaspartylglutamic acid
NAAG Spaglumic acid
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