Name | n-acetyl-asp-glu |
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Synonyms |
N-Acetyl-L-aspartyl-L-glutamic acid
N-acetyl-1-aspartylglutamic acid NAAGA AC-ASP-GLU SPAGLUMIC ACID N-(N-Acetyl-L-a-aspartyl)-L-glutamic Acid N-acetyl-L-aspartyl-L-glutamate N-Acetyl-L-α-aspartyl-L-glutamic acid isospaglumic acid L-Glutamic acid, N-acetyl-L-α-aspartyl- AC-ASP-GLU H2O AC-ASP-GLU-OH MFCD00076652 Tacrine hydrochloride N-acetyl-aspartatylglutamate N-(N-Acetyl-L-α-aspartyl)-L-glutamic acid glutamic acid, N-acetylaspartyl- ACETYL-D-E Naaxia NAAG N-Acetylaspartylglutamic acid NAAG Spaglumic acid |
Description | Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1]. |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 769.5±60.0 °C at 760 mmHg |
Molecular Formula | C11H16N2O8 |
Molecular Weight | 304.253 |
Flash Point | 419.1±32.9 °C |
Exact Mass | 304.090668 |
PSA | 170.10000 |
LogP | -1.96 |
Vapour Pressure | 0.0±5.7 mmHg at 25°C |
Index of Refraction | 1.540 |
Storage condition | −20°C |
Water Solubility | H2O: 50 mg/mL |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2924199090 |
Precursor 1 | |
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DownStream 2 | |
HS Code | 2924199090 |
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Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |