ELN484228

Modify Date: 2024-01-19 16:17:14

ELN484228 Structure
ELN484228 structure
Common Name ELN484228
CAS Number 312-63-0 Molecular Weight 251.27700
Density 1.374g/cm3 Boiling Point 379.1ºC at 760 mmHg
Molecular Formula C12H10FNO2S Melting Point N/A
MSDS Chinese USA Flash Point 183ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of ELN484228


ELN484228 is a blocker of α-synuclein which is a key protein in Parkinson’s disease.

 Names

Name N-(4-fluorophenyl)benzenesulfonamide
Synonym More Synonyms

 ELN484228 Biological Activity

Description ELN484228 is a blocker of α-synuclein which is a key protein in Parkinson’s disease.
Related Catalog
Target

α-synuclein[1]

References

[1]. Tóth G, et al. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One. 2014 Feb 14;9(2):e87133.

 Chemical & Physical Properties

Density 1.374g/cm3
Boiling Point 379.1ºC at 760 mmHg
Molecular Formula C12H10FNO2S
Molecular Weight 251.27700
Flash Point 183ºC
Exact Mass 251.04200
PSA 54.55000
LogP 3.78030
Index of Refraction 1.618
Storage condition 2-8℃

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport
HS Code 2935009090

 Synthetic Route

~76%

ELN484228 Structure

ELN484228

CAS#:312-63-0

Literature: Pan, Changduo; Cheng, Jiang; Wu, Huayue; Ding, Jinchang; Liu, Miaochang Synthetic Communications, 2009 , vol. 39, # 12 p. 2082 - 2092

~88%

ELN484228 Structure

ELN484228

CAS#:312-63-0

Literature: Grivas, Spiros; Olsson, Kjell Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1985 , vol. 39, # 1 p. 31 - 34

~%

ELN484228 Structure

ELN484228

CAS#:312-63-0

Literature: Kravtsov, D. N.; Peregudov, A. S.; Ivanov, V. F. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, # 3 p. 468 - 474 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 3 p. 522 - 528

~%

ELN484228 Structure

ELN484228

CAS#:312-63-0

Literature: Kravtsov, D. N.; Peregudov, A. S.; Ivanov, V. F. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, # 3 p. 468 - 474 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 3 p. 522 - 528

~%

ELN484228 Structure

ELN484228

CAS#:312-63-0

Literature: Kravtsov, D. N.; Peregudov, A. S.; Ivanov, V. F. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, # 3 p. 468 - 474 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 3 p. 522 - 528

~%

ELN484228 Structure

ELN484228

CAS#:312-63-0

Literature: Jones Journal of the Chemical Society, 1938 , p. 1414 Journal of the Chemical Society, 1942 , p. 418

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

4-Fluor-N-phenylbenzolsulfonamid
4'-fluorobenzenesulfonanilide
ELN484228
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