PROTO-1

Modify Date: 2024-01-11 13:51:02

PROTO-1 Structure
PROTO-1 structure
 Common Name PROTO-1
CAS Number 312951-85-2 Molecular Weight 378.876
Density 1.4±0.1 g/cm3 Boiling Point 430.9±45.0 °C at 760 mmHg
Molecular Formula C17H19ClN4O2S Melting Point N/A
MSDS N/A Flash Point 214.4±28.7 °C

 Use of PROTO-1


PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).Target:PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with 1 and 10 μM PROTO-1 results in significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar.[2]

 Names

Name PROTO-1
Synonym More Synonyms

 PROTO-1 Biological Activity

Description PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).Target:PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with 1 and 10 μM PROTO-1 results in significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar.[2]
Related Catalog
References

[1]. Rubel, et al. COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH

[2]. Owens KN, et al. Identification of genetic and chemicalm modulators of zebrafish mechanosensory hair cell death. PLoS Genet. 2008 Feb 29;4(2):e1000020.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 430.9±45.0 °C at 760 mmHg
Molecular Formula C17H19ClN4O2S
Molecular Weight 378.876
Flash Point 214.4±28.7 °C
Exact Mass 378.091736
LogP 4.30
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.698
Storage condition 2-8℃

 Synonyms

Thieno[2,3-c]pyridine-3-carboxamide, 2-[[[(4-chlorophenyl)amino]carbonyl]amino]-6-ethyl-4,5,6,7-tetrahydro-
2-{[(4-Chlorophenyl)carbamoyl]amino}-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
MFCD01923572
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Chemsrc provides PROTO-1(CAS#:312951-85-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of PROTO-1 are included as well.>> amp version: PROTO-1

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