Virginiamycin B

Modify Date: 2024-01-01 17:16:03

Virginiamycin B Structure
Virginiamycin B structure
Common Name Virginiamycin B
CAS Number 3131-03-1 Molecular Weight 866.95800
Density 1.38g/cm3 Boiling Point 1202.1ºC at 760mmHg
Molecular Formula C45H54N8O10 Melting Point N/A
MSDS N/A Flash Point 680.8ºC

 Use of Virginiamycin B


Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]

 Names

Name pristinamycin IA
Synonym More Synonyms

 Virginiamycin B Biological Activity

Description Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]
Related Catalog
References

[1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

 Chemical & Physical Properties

Density 1.38g/cm3
Boiling Point 1202.1ºC at 760mmHg
Molecular Formula C45H54N8O10
Molecular Weight 866.95800
Flash Point 680.8ºC
Exact Mass 866.39600
PSA 227.96000
LogP 2.13220
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZA4870000
CHEMICAL NAME :
Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)-
CAS REGISTRY NUMBER :
3131-03-1
BEILSTEIN REFERENCE NO. :
0078387
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C45-H54-N8-O10
MOLECULAR WEIGHT :
867.07
WISWESSER LINE NOTATION :
T F5-19-6 ANV DNV JNV MMV QOV TMV A&VTJ C1R DN1&1& D1 L2 P1 SR& OMV- BT6NJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,367,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

 Safety Information

RIDADR UN 3172
Packaging Group III
Hazard Class 6.1(b)

 Synonyms

Antibiotic PA 114B
Mikamycin B
Ostreogrycin B
PA 114B
Pristinamycin IA
Antibiotic PA 114 B1
Vernamycin BA
Mikamycin IA
Streptogramin B
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