A 922500

Modify Date: 2024-01-03 17:40:06

A 922500 structure	Common Name	A 922500
	CAS Number	314-19-2	Molecular Weight	303.783
	Density	N/A	Boiling Point	473.4ºC at 760mmHg
	Molecular Formula	C₁₇H₁₈ClNO₂	Melting Point	195ºC (decomposes)
	MSDS	N/A	Flash Point	268.8ºC

Use of A 922500

Apomorphine Hydrochloride, also known as APL-130277 and TAK-251, is a dopamine D2 agonist used for the treatment of Parkinson's disease. Apomorphine also promotes intraneuronal amyloid-β (Aβ) degradation and improves memory function in an Alzheimer's disease model. Protein levels of two types of serine-phosphorylated insulin receptor substrate-1 (IRS-1), pS616 and pS636/639, significantly decreased following Apomorphine treatment in the 13-month-old 3xTg-AD mice brain, suggesting improved brain insulin resistance.

Name	(R)-(-)-Apomorphine hydrochloride,(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diolhydrochloride
Synonym	More Synonyms

Boiling Point	473.4ºC at 760mmHg
Melting Point	195ºC (decomposes)
Molecular Formula	C₁₇H₁₈ClNO₂
Molecular Weight	303.783
Flash Point	268.8ºC
Exact Mass	303.102600
PSA	43.70000
LogP	3.58980

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ1750000

CHEMICAL NAME :: 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 314-19-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H17-N-O2.Cl-H

MOLECULAR WEIGHT :: 303.81

WISWESSER LINE NOTATION :: T C6666 1A Q KN&TT&J DQ EQ K1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 137,17,1984

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)

neomorphine

CAS#:86709-01-5

A 922500

CAS#:314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

3-O-acetylneomo...

CAS#:86680-37-7

A 922500

CAS#:314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

3-O-acetyl-6-O-...

CAS#:86680-39-9

A 922500

CAS#:314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

(5alpha,6alpha)...

CAS#:467-14-1

A 922500

CAS#:314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

A727500

CAS#:58-00-4

A 922500

CAS#:314-19-2

Literature: WO2009/38958 A1, ; Page/Page column 5 ;

demethoxyoripavine

CAS#:86545-92-8

A 922500

CAS#:314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

Precursor 6
CAS#:86709-01-5 neomorphine CAS#:86680-37-7 3-O-acetylneomo... CAS#:86680-39-9 3-O-acetyl-6-O-... CAS#:467-14-1 (5alpha,6alpha)...
CAS#:58-00-4 A727500 CAS#:86545-92-8 demethoxyoripavine
DownStream 1
CAS#:18605-43-1 (Z,E)-9,11-TDDA

6aβ-Noraporphine-10,11-diol, 6-methyl-, hydrochloride

apomorphine HCl

6aβ-Aporphine-10,11-diol, hydrochloride (8CI)

apomorphinechloride

EINECS 206-243-0

4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-, hydrochloride (1:1)

(6aR)-6-méthyl-5,6,6a,7-tétrahydro-4H-dibenzo[de,g]quinoléine-10,11-diol chlorhydrate

(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride

4H-dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-, hydrochloride

Apomorphine hydrochoride

(-)-apomorphine hydrochloride

(6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]chinolin-10,11-diolhydrochlorid

(6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride (1:1)

6aβ-Aporphine-10,11-diol, hydrochloride

apomorphiniumchloride

6-Methyl-6ab-noraporphine-10,11-diol Hydrochloride

6ab-Aporphine-10,11-diol Hydrochloride

APOMORPHINE HYDROCHLORIDE

UPRIMA

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (R)-(-)-Apomorphine hydrochloride
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Apomorphine Hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Apomorphine Hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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A 922500

Use of A 922500

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms