migrastatin

Modify Date: 2024-01-09 10:17:19

migrastatin Structure
migrastatin structure
Common Name migrastatin
CAS Number 314245-65-3 Molecular Weight 489.60100
Density N/A Boiling Point N/A
Molecular Formula C27H39NO7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of migrastatin


Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration[1][2].

 Names

Name migrastatin
Synonym More Synonyms

 migrastatin Biological Activity

Description Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration[1][2].
Related Catalog
Target

Fascin1[1]

In Vitro Migrastatin (100 μM) leads to the disorganization of the bundles. Migrastatin (100 μM; HCT-116 and DLD-1 cells) prevents cell migration[1].
References

[1]. Montoro-García S, et al. Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells. J Mol Med (Berl). 2020;98(3):383-394.

[2]. Nakae K, et al. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000;53(10):1130-1136.

 Chemical & Physical Properties

Molecular Formula C27H39NO7
Molecular Weight 489.60100
Exact Mass 489.27300
PSA 122.49000
LogP 3.46690

 Safety Information

Hazard Codes Xi

 Synonyms

Migrastatin
4-[(5S)-5-[(2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxo-1-oxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl]piperidine-2,6-dione
4-{(5S)-5-[(2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl]-4-oxohexyl}piperidine-2,6-dione