VU 0285683

Modify Date: 2024-03-02 10:00:26

VU 0285683 Structure
VU 0285683 structure
Common Name VU 0285683
CAS Number 327056-22-4 Molecular Weight 266.23000
Density N/A Boiling Point N/A
Molecular Formula C14H7FN4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU 0285683


VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].

 Names

Name 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

 VU 0285683 Biological Activity

Description VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety[1].
Related Catalog
References

[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.  

 Chemical & Physical Properties

Molecular Formula C14H7FN4O
Molecular Weight 266.23000
Exact Mass 266.06000
PSA 75.60000
LogP 2.80938
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