FPR A14
Modify Date: 2024-01-19 17:32:30
FPR A14 structure
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Common Name | FPR A14 | ||
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| CAS Number | 329691-12-5 | Molecular Weight | 404.41500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H20N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FPR A14FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2]. |
| Name | N'-(4-(benzyloxy)-3-methoxybenzylidene)benzo[d][1,3]dioxole-5-carbohydrazide |
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| Description | FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2]. |
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| Related Catalog | |
| In Vitro | FPR-A14 (化合物 14) 激活 Ca2+ 释放，在人中性粒细胞中 EC50 为 630 nM。FPR-A14 是一种中性粒细胞化学引诱剂，剂量依赖性地诱导中性粒细胞迁移，EC50 值为 42 nM[1]。 FPR-A14 (1-10 μM; 48 小时) 在小鼠神经母细胞瘤 N2a 细胞中引起细胞分化百分比显着增加，分别为 4μM (32.0%)、6μM (64.9%)、8μM (89.1%) 和 10μM (93.3%)。FPRa14 (100μM) 在 IMR-32 和 SH-SY5Y 细胞中产生相似的作用[2]。 |
| References |
| Molecular Formula | C23H20N2O5 |
|---|---|
| Molecular Weight | 404.41500 |
| Exact Mass | 404.13700 |
| PSA | 78.38000 |
| LogP | 4.15770 |
| Storage condition | -20°C |