I2906
Modify Date: 2024-01-14 15:06:26
I2906 structure
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Common Name | I2906 | ||
|---|---|---|---|---|
| CAS Number | 331963-29-2 | Molecular Weight | 443.57900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H37N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of I2906I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.IC50 Value: Target: AntibacterialUnder in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). |
| Name | 1-ethyl-4-hydroxy-2-oxo-N'-tridecanoylquinoline-3-carbohydrazide |
|---|---|
| Synonym | More Synonyms |
| Description | I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.IC50 Value: Target: AntibacterialUnder in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05). |
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| Related Catalog | |
| References |
| Molecular Formula | C25H37N3O4 |
|---|---|
| Molecular Weight | 443.57900 |
| Exact Mass | 443.27800 |
| PSA | 107.41000 |
| LogP | 6.21410 |
| Storage condition | 2-8℃ |
| i2906 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: I2906
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: I-2906
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: I-2906
- Price: $Inquiry/250mg $Inquiry/1g $300.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: $147/10mM*1mLinDMSO
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