RGD-4C trifluoroacetate salt

Modify Date: 2024-01-17 11:59:35

RGD-4C trifluoroacetate salt Structure
RGD-4C trifluoroacetate salt structure
 Common Name RGD-4C trifluoroacetate salt
CAS Number 332179-76-7 Molecular Weight 1145.29
Density N/A Boiling Point N/A
Molecular Formula C42H60N14O16S4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RGD-4C trifluoroacetate salt


RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3].

 Names

Name RGD-4C trifluoroacetate salt

 RGD-4C trifluoroacetate salt Biological Activity

Description RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3].
Related Catalog
In Vitro RGD-4C (2.5, 5, 10 μg/mL) inhibits BAE cell proliferation by synthetic form modified with endostatin-derived peptides[2].
In Vivo RGD-4C (9.11 mg/kg; injection; single dose) inhibits the growth of B16F10 mouse melanoma in vivo[2]. Modified RGD-4C fused with the N-terminus of plant-derived single-chain ribosome inactivating protein saporin (SAP) (called RGD-SAP), (diluted in sodium chloride, 0.9%; i.v.; 200 µL; every 5 days, for 3 times) exerts anti-tumor activity in a model of muscle invasive bladder cancer[3]. RGD-SAP in combination with mitomycin C, a chemotherapeutic drug, increases the survival of mice bearing orthotopic bladder cancer with no evidence of systemic toxicity[3].
References

[1]. Assa-Munt N, et al. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry. 2001 Feb 27;40(8):2373-8.  

[2]. Yin R, et al. Effect of RGD-4C position is more important than disulfide bonds on antiangiogenic activity of RGD-4C modified endostatin derived synthetic polypeptide. Bioconjug Chem. 2010 Jul 21;21(7):1142-7.  

[3]. Zuppone S, et al. A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer. Front Oncol. 2022 Apr 11;12:846958.  

 Chemical & Physical Properties

Molecular Formula C42H60N14O16S4
Molecular Weight 1145.29
Top Suppliers:I want be here

Get all suppliers and price by the below link:

RGD-4C trifluoroacetate salt suppliers

RGD-4C trifluoroacetate salt price

Related Compounds: More...
Galacto-RGD trifluoroacetate salt
922175-70-0
(S)-2-(2-((S)-2-Amino-5-guanidinopentanamido)acetamido)succinic acid trifluoroacetate
2378808-45-6
RGD Negative Control trifluoroacetate salt
756500-24-0
3-Ketosphingosine trifluoroacetate salt
19767-16-9
Mastoparan 7 trifluoroacetate salt
145854-59-7
Kisspeptin 234 TFA
1848962-29-7
Alarin (human) trifluoroacetate salt
909409-86-5
BMS 345541 (trifluoroacetate salt)
2320261-79-6
3-Bromotyrosine (trifluoroacetate salt)
2320428-62-2
Chemsrc provides RGD-4C trifluoroacetate salt(CAS#:332179-76-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of RGD-4C trifluoroacetate salt are included as well.>> amp version: RGD-4C trifluoroacetate salt

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved