Prostaglandin F2α methyl ester

Modify Date: 2024-01-06 17:39:15

Prostaglandin F2α methyl ester Structure
Prostaglandin F2α methyl ester structure
Common Name Prostaglandin F2α methyl ester
CAS Number 33854-16-9 Molecular Weight 368.508
Density 1.1±0.1 g/cm3 Boiling Point 494.2±45.0 °C at 760 mmHg
Molecular Formula C21H36O5 Melting Point N/A
MSDS USA Flash Point 161.9±22.2 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Names

Name Prostaglandin F2α methyl ester
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 494.2±45.0 °C at 760 mmHg
Molecular Formula C21H36O5
Molecular Weight 368.508
Flash Point 161.9±22.2 °C
Exact Mass 368.256287
PSA 86.99000
LogP 2.70
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.548

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UK8021500
CHEMICAL NAME :
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, methyl ester, (5Z,9-alpha,11-alpha, 13E,15S)-
CAS REGISTRY NUMBER :
33854-16-9
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H36-O5
MOLECULAR WEIGHT :
368.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
80 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 102,620,1983 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
80 ug/kg
SEX/DURATION :
female 7 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 102,620,1983
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
480 ug/kg
SEX/DURATION :
female 4 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 186,67,1973

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H319-H336
Supplemental HS Repeated exposure may cause skin dryness or cracking.
Precautionary Statements P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
Hazard Codes F,Xi
Risk Phrases 11-36-66-67
RIDADR UN 1231 3/PG 2

 Synthetic Route

 Articles17

More Articles
Determination of 9alpha, 11beta prostaglandin F2 in human urine. combination of solid-phase extraction and radioimmunoassay.

Prostaglandins Leukot. Essent. Fatty Acids 65(5-6) , 271-80, (2001)

This paper describes a new iodine-125 radioimmunoassay of 9alpha ,11beta-PGF2, and its use for the determination of urinary 9alpha,11beta-prostaglandin F2 after a selective one-step solid-phase extrac...

A comparative study of intravesical instillation of 15(s) 15 Me alpha and alum in the management of persistent hematuria of vesical origin.

Int. J. Clin. Pharmacol. Ther. Toxicol. 30(1) , 7-12, (1992)

A prospective randomized, controlled study was done to compare the efficacy and safety of 15(s) 15 Me PGF2 alpha intravesical instillation and 1% alum vesical irrigation in the control of vesical hema...

[Role of prostaglandins F and E in regulation of bronchial activity].

Pol. Arch. Med. Wewn. 93 , 179, (1995)

Prostaglandins (PGs) belong to the family of eicosanoids. A main substrate in their biosynthesis is arachidonic acid. Involvement of PGs in regulation of bronchial activity is a complex process and fa...

 Synonyms

Methyl (5Z,9α,11α,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oate
prostaglandins f2alpha methyl ester
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, methyl ester, (5Z,9α,11α,13E,15S)-
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