4-Hydroxyacetophenone oxime

Modify Date: 2024-01-10 09:16:36

4-Hydroxyacetophenone oxime Structure
4-Hydroxyacetophenone oxime structure
Common Name 4-Hydroxyacetophenone oxime
CAS Number 34523-34-7 Molecular Weight 151.16300
Density 1.246g/cm3 Boiling Point 294.8ºC at 760mmHg
Molecular Formula C8H9NO2 Melting Point 143 °C
MSDS N/A Flash Point 132.1ºC

 Use of 4-Hydroxyacetophenone oxime


4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic drug[1][2].

 Names

Name 4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one
Synonym More Synonyms

 4-Hydroxyacetophenone oxime Biological Activity

Description 4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic drug[1][2].
Related Catalog
References

[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.

[2]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.

 Chemical & Physical Properties

Density 1.246g/cm3
Boiling Point 294.8ºC at 760mmHg
Melting Point 143 °C
Molecular Formula C8H9NO2
Molecular Weight 151.16300
Flash Point 132.1ºC
Exact Mass 151.06300
PSA 52.82000
LogP 1.59040
Index of Refraction 1.591

 Safety Information

Hazard Codes Xn
HS Code 2928000090

 Synthetic Route

~98%

4-Hydroxyacetophenone oxime Structure

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CAS#:34523-34-7

Literature: Baleizao, Carlos; Corma, Avelino; Garcia, Hermenegildo; Leyva, Antonio Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 439 - 446 Title/Abstract Full Text View citing articles Show Details Corma, Avelino; Garcia, Hermenegildo; Leyva, Antonio Tetrahedron, 2005 , vol. 61, # 41 p. 9848 - 9854

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4-Hydroxyacetophenone oxime Structure

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CAS#:34523-34-7

Literature: US6228350 B1, ;

~77%

4-Hydroxyacetophenone oxime Structure

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CAS#:34523-34-7

Literature: Tokmadzhyan Russian Journal of Organic Chemistry, 2011 , vol. 47, # 11 p. 1746 - 1749

~0%

4-Hydroxyacetophenone oxime Structure

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CAS#:34523-34-7

Literature: Journal of Organic Chemistry, , vol. 59, # 19 p. 5814 - 5817

 Customs

HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

p-hydroxyacetophenone oxime
4-hydroxyphenyl methyl ketone oxime
methyl p-hydroxyphenyl ketone oxime
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