Trimethylcolchicinic acid methyl ether

Modify Date: 2024-01-20 15:28:39

Trimethylcolchicinic acid methyl ether Structure
Trimethylcolchicinic acid methyl ether structure
 Common Name Trimethylcolchicinic acid methyl ether
CAS Number 3476-50-4 Molecular Weight 357.40000
Density 1.25g/cm3 Boiling Point 626.6ºC at 760mmHg
Molecular Formula C20H23NO5 Melting Point N/A
MSDS N/A Flash Point 287ºC

 Use of Trimethylcolchicinic acid methyl ether


Trimethylcolchicinic acid methyl ether, Antimitotic agent that intercepts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signal.

 Names

Name Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.25g/cm3
Boiling Point 626.6ºC at 760mmHg
Molecular Formula C20H23NO5
Molecular Weight 357.40000
Flash Point 287ºC
Exact Mass 357.15800
PSA 80.01000
LogP 3.39450
Index of Refraction 1.597

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0785000
CHEMICAL NAME :
Colchicine, N-deacetyl-
CAS REGISTRY NUMBER :
3476-50-4
BEILSTEIN REFERENCE NO. :
2822162
LAST UPDATED :
199707
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C20-H23-N-O5
MOLECULAR WEIGHT :
357.44
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JZ NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
46 mg/kg
REFERENCE :
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

 Safety Information

WGK Germany 3
HS Code 2922509090

 Synthetic Route

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

N-deacethylcolchicine
N-deacetylcolchicine
trimethylcolchicinic acid methyl ether
deacetylcolchicine
Desacetylcolchicine
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Trimethylcolchicinic acid methyl ether suppliers

Trimethylcolchicinic acid methyl ether price

Related Compounds: More...
DESACETYLCOLCHICINE-d-TARTRATE
49720-72-1
3-(1-butenyl)-2,2-dimethylcyclo-propanoic acid methyl ether
52314-69-9
(4S,5S)-4-benzyl-2-oxo-oxazolidine-5-carboxylic acid methyl ether
162221-36-5
Methyl 4-(1H-pyrazol-5-yl)benzoate
179057-10-4
Benzamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
63989-75-3
Maleic acid-methyl vinyl ether polymer
25153-40-6
xanthurenic acid 8-methyl ether
2929-14-8
trans-1-(methyl ether)-cyclopropyl-2-boronic acid pinacol ester
1093207-37-4
acetic acid,4-(methoxymethyl)phenol
38177-36-5
2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)pyridine-3-carbaldehyde
1695048-37-3
2,4-Imidazolidinedione, 5-acetyl-1-butyl-3-phenyl-
1262326-16-8
2-{[(benzyloxy)carbonyl]amino}-3-(1-ethyl-1H-pyrazol-4-yl)propanoic acid
1698120-34-1
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
(3R)-3-amino-4-ethylhexanamide
1604380-90-6
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
1-(3-bromo-2-methylphenyl)-1H-pyrazole-3-carboxylic acid
1690848-81-7
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
2-Formamidohept-6-ynoic acid
1565499-56-0
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
Chemsrc provides Trimethylcolchicinic acid methyl ether(CAS#:3476-50-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Trimethylcolchicinic acid methyl ether are included as well.>> amp version: Trimethylcolchicinic acid methyl ether

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved