Demecolcine, N-methyl-

Modify Date: 2024-01-09 19:16:50

Demecolcine, N-methyl- Structure
Demecolcine, N-methyl- structure
 Common Name Demecolcine, N-methyl-
CAS Number 7336-44-9 Molecular Weight 385.45300
Density 1.2g/cm3 Boiling Point 619.7ºC at 760 mmHg
Molecular Formula C22H27NO5 Melting Point N/A
MSDS N/A Flash Point 328.6ºC

 Names

Name (7S)-7-(dimethylamino)-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2g/cm3
Boiling Point 619.7ºC at 760 mmHg
Molecular Formula C22H27NO5
Molecular Weight 385.45300
Flash Point 328.6ºC
Exact Mass 385.18900
PSA 57.23000
LogP 3.29710
Index of Refraction 1.581

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0792000
CHEMICAL NAME :
Colchicine, N-deacetyl-N,N-dimethyl-
CAS REGISTRY NUMBER :
7336-44-9
LAST UPDATED :
198706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H27-N-O5
MOLECULAR WEIGHT :
385.50
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JN1&1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

 Synthetic Route

(-)-Demecolcine structure

(-)-Demecolcine

CAS#:477-30-5

methyl iodide structure

methyl iodide

CAS#:74-88-4

~%

Demecolcine, N-methyl- Structure

Demecolcine, N-...

CAS#:7336-44-9

Literature: Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Show Details Santavy Collection of Czechoslovak Chemical Communications, 1951 , vol. 16/17, p. 676,683 Show Details Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29
Formaldehyde structure

Formaldehyde

CAS#:50-00-0

Formic Acid structure

Formic Acid

CAS#:64-18-6

(-)-Demecolcine structure

(-)-Demecolcine

CAS#:477-30-5

~%

Demecolcine, N-methyl- Structure

Demecolcine, N-...

CAS#:7336-44-9

Literature: Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Show Details Ueno Yakugaku Zasshi, 1953 , vol. 73, p. 1232,1233 Proceedings of the Japan Academy, 1953 , vol. 29, p. 266,269
Formaldehyde structure

Formaldehyde

CAS#:50-00-0

Formic Acid structure

Formic Acid

CAS#:64-18-6

Trimethylcolchicinic acid methyl ether structure

Trimethylcolchi...

CAS#:3476-50-4

~%

Demecolcine, N-methyl- Structure

Demecolcine, N-...

CAS#:7336-44-9

Literature: Kiselew Doklady Akademii Nauk SSSR, 1954 , vol. 96, p. 527 Chem.Abstr., 1955 , p. 9005

 Synonyms

N,N-dimethyldeacetylcolchicine
N-Methyldemecolcine
N-Deacetyl-N,N-dimethylcolchicine
Demecolcine,N-methyl
N,N-Dimethyl-desacetyl-colchicin
N-Methyl-demecolcin
Methylademecolcine,N
N-methyldemocolcine
COLCHICINE,N-DEACETYL-N,N-DIMETHYL
N-Methylcolchamine
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