palmatine

Modify Date: 2024-01-02 18:03:46

palmatine Structure
palmatine structure
 Common Name palmatine
CAS Number 3486-67-7 Molecular Weight 352.403
Density N/A Boiling Point N/A
Molecular Formula C21H22NO4+ Melting Point 205ºC
MSDS N/A Flash Point N/A

 Use of palmatine


Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].

 Names

Name palmatine
Synonym More Synonyms

 palmatine Biological Activity

Description Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1].
Related Catalog
Target

IDO1

In Vitro Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1].
In Vivo Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1]. Animal Model: DSS- induced Colitis BALB/c mice model[1] Dosage: 50 or 100 mg/kg; 7 days Administration: Oral administration Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells.
References

[1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46.

 Chemical & Physical Properties

Melting Point 205ºC
Molecular Formula C21H22NO4+
Molecular Weight 352.403
Exact Mass 352.154327
PSA 40.80000
LogP -1.12

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9890000
CHEMICAL NAME :
Berbinium, 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-
CAS REGISTRY NUMBER :
3486-67-7
BEILSTEIN REFERENCE NO. :
1555498
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H22-N-O4
MOLECULAR WEIGHT :
352.44
WISWESSER LINE NOTATION :
T D6 B666 KN&TT&J GO1 HO1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,129,1968

 Safety Information

Hazard Codes Xi
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Calystigine
7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium
MFCD00221758
palmatine
Burasaine
2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium
palmatin
berbericinine
7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium
Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-
o,o-dimethyldemethyleneberberine
Hindarinine
5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium
Common fibraurea stem
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