9-AMINO-6-CHLORO-2-METHOXYACRIDINE

Modify Date: 2024-01-08 12:35:59

9-AMINO-6-CHLORO-2-METHOXYACRIDINE Structure
9-AMINO-6-CHLORO-2-METHOXYACRIDINE structure
Common Name 9-AMINO-6-CHLORO-2-METHOXYACRIDINE
CAS Number 3548-09-2 Molecular Weight 258.70300
Density 1.367g/cm3 Boiling Point 475.1ºC at 760mmHg
Molecular Formula C14H11ClN2O Melting Point N/A
MSDS Chinese USA Flash Point 241.2ºC
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of 9-AMINO-6-CHLORO-2-METHOXYACRIDINE


9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].

 Names

Name 9-Amino-6-chloro-2-methoxyacridine
Synonym More Synonyms

 9-AMINO-6-CHLORO-2-METHOXYACRIDINE Biological Activity

Description 9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H+/solute antiport system[1].
Related Catalog
References

[1]. Carqueijeiro I, et al. Analytical and Fluorimetric Methods for the Characterization of the Transmembrane Transport of Specialized Metabolites in Plants. Methods Mol Biol. 2016;1405:121-135.

 Chemical & Physical Properties

Density 1.367g/cm3
Boiling Point 475.1ºC at 760mmHg
Molecular Formula C14H11ClN2O
Molecular Weight 258.70300
Flash Point 241.2ºC
Exact Mass 258.05600
PSA 48.14000
LogP 4.21340
Index of Refraction 1.734
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR7330000
CHEMICAL NAME :
Acridine, 9-amino-3-chloro-7-methoxy-
CAS REGISTRY NUMBER :
3548-09-2
BEILSTEIN REFERENCE NO. :
0226315
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H11-Cl-N2-O
MOLECULAR WEIGHT :
258.72
WISWESSER LINE NOTATION :
T C666 BNJ EG IZ LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 28,1,1947

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H315-H319-H335-H351
Precautionary Statements P261-P281-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R36/37/38
Safety Phrases 22-26-36
RIDADR NONH for all modes of transport
RTECS AR7330000
HS Code 2933990090

 Synthetic Route

~68%

9-AMINO-6-CHLORO-2-METHOXYACRIDINE Structure

9-AMINO-6-CHLOR...

CAS#:3548-09-2

Literature: Bonse, Susanne; Santelli-Rouvier, Christiane; Barbe, Jacques; Krauth-Siegel, R. Luise Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5448 - 5454

~84%

9-AMINO-6-CHLORO-2-METHOXYACRIDINE Structure

9-AMINO-6-CHLOR...

CAS#:3548-09-2

Literature: Gemma, Sandra; Kukreja, Gagan; Tripaldi, Pierangela; Altarelli, Maria; Bernetti, Matteo; Franceschini, Silvia; Savini, Luisa; Campiani, Giuseppe; Fattorusso, Caterina; Butini, Stefania Tetrahedron Letters, 2008 , vol. 49, # 13 p. 2074 - 2077

~%

9-AMINO-6-CHLORO-2-METHOXYACRIDINE Structure

9-AMINO-6-CHLOR...

CAS#:3548-09-2

Literature: , vol. 39, # 11 p. 1626 - 1628

~%

9-AMINO-6-CHLORO-2-METHOXYACRIDINE Structure

9-AMINO-6-CHLOR...

CAS#:3548-09-2

Literature: Nippon Kagaku Zasshi, , vol. 75, p. 475,476 Chem.Abstr., , p. 10297

~%

9-AMINO-6-CHLORO-2-METHOXYACRIDINE Structure

9-AMINO-6-CHLOR...

CAS#:3548-09-2

Literature: , vol. 39, # 11 p. 1626 - 1628

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

MFCD00083236
6-chloro-2-methoxyacridin-9-amine