R-116010
Modify Date: 2024-02-19 10:15:24
R-116010 structure
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Common Name | R-116010 | ||
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| CAS Number | 355860-40-1 | Molecular Weight | 377.506 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 569.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H23N5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 298.4±32.9 °C | |
Use of R-116010A potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM; enhances the ATRA-mediated antiproliferative activity in a concentration-dependent manner, significantly inhibits the growth of murine oestrogen-independent TA3-Ha mammary tumour in vivo. |
| Name | N1-(1,3-Benzothiazol-2-yl)-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl-1,2-benzenediamine |
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| Synonym | More Synonyms |
| Description | A potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM; enhances the ATRA-mediated antiproliferative activity in a concentration-dependent manner, significantly inhibits the growth of murine oestrogen-independent TA3-Ha mammary tumour in vivo. |
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| References | References 1. Thatcher JE, et al. Mol Pharmacol. 2011 Aug;80(2):228-39. 2. Van Heusden J, et al. Br J Cancer. 2002 Feb 12;86(4):605-11. View Related Products by Target Cytochrome P450 (CYPs) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 569.7±60.0 °C at 760 mmHg |
| Molecular Formula | C21H23N5S |
| Molecular Weight | 377.506 |
| Flash Point | 298.4±32.9 °C |
| Exact Mass | 377.167419 |
| LogP | 4.19 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.669 |
| 1,2-Benzenediamine, N1-2-benzothiazolyl-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl- |
| N1-(1,3-Benzothiazol-2-yl)-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl-1,2-benzenediamine |