355860-40-1
355860-40-1 structure
- Name: R-116010
- Chemical Name: N1-(1,3-Benzothiazol-2-yl)-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl-1,2-benzenediamine
- CAS Number: 355860-40-1
- Molecular Formula: C21H23N5S
- Molecular Weight: 377.506
- Create Date: 2020-01-11 22:48:51
- Modify Date: 2024-02-19 10:15:24
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A potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM; enhances the ATRA-mediated antiproliferative activity in a concentration-dependent manner, significantly inhibits the growth of murine oestrogen-independent TA3-Ha mammary tumour in vivo.
| Name | N1-(1,3-Benzothiazol-2-yl)-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl-1,2-benzenediamine |
|---|---|
| Synonyms |
1,2-Benzenediamine, N1-2-benzothiazolyl-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl-
N1-(1,3-Benzothiazol-2-yl)-4-[(1S)-1-(1H-imidazol-1-yl)propyl]-N2,N2-dimethyl-1,2-benzenediamine |
| Description | A potent CYP26A1 inhibitor with IC50 of 10 nM, potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with IC50 of 8.7 nM; enhances the ATRA-mediated antiproliferative activity in a concentration-dependent manner, significantly inhibits the growth of murine oestrogen-independent TA3-Ha mammary tumour in vivo. |
|---|---|
| References | References 1. Thatcher JE, et al. Mol Pharmacol. 2011 Aug;80(2):228-39. 2. Van Heusden J, et al. Br J Cancer. 2002 Feb 12;86(4):605-11. View Related Products by Target Cytochrome P450 (CYPs) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 569.7±60.0 °C at 760 mmHg |
| Molecular Formula | C21H23N5S |
| Molecular Weight | 377.506 |
| Flash Point | 298.4±32.9 °C |
| Exact Mass | 377.167419 |
| LogP | 4.19 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.669 |