Pressinoic acid

Modify Date: 2024-01-02 12:41:50

Pressinoic acid Structure
Pressinoic acid structure
Common Name Pressinoic acid
CAS Number 35748-51-7 Molecular Weight 774.86400
Density 1.325g/cm3 Boiling Point 1373ºC at 760mmHg
Molecular Formula C33H42N8O10S2 Melting Point N/A
MSDS N/A Flash Point 784.2ºC

 Use of Pressinoic acid


Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior.

 Names

Name 19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxylic acid
Synonym More Synonyms

 Pressinoic acid Biological Activity

Description Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior.
Related Catalog
Target

Oxytocin[1]

In Vitro Pressinoic acid, a synthetic hexapeptide that corresponds to the ring of vasopressin, exhibits corticotrophin-releasing activity in vitro in doses of 3 and 30 ng/mL[1].
Cell Assay Single halved pituitary glands of female CFE rats weighing 100 to 150 g are preincubated for two hours in Krebs-Ringer-bicarbonate-glucose (2%) medium under 5% CO2 in O2, and then for one hour periods each with 300 ng. lysine vasopressin and the sample of vasopressin ring peptide Pressinoic Acid. The incubations are separated by a one hour ish period. The media from the pituitary incubations are added to rat adrenal quarters superfused for estimation of the steroidogenic response to the corticotrophin released. The steroidogenie effect of the unstimulated release of corticotrophin by the pituitary tissue and the possible steroidogenic effect of the peptide directly on the adrenal tissue are measured together by adding the peptide to the media from pituitary tissue incubated without peptide for one hour[1].
References

[1]. Saffran M, et al. Pressinoic acid: a peptide with potent corticotrophin-releasing activity. Biochem Biophys Res Commun. 1972 Nov 1;49(3):748-51.

[2]. Langs DA, et al. Structure of pressinoic acid: the cyclic moiety of vasopressin. Science. 1986 Jun 6;232(4755):1240-2.

 Chemical & Physical Properties

Density 1.325g/cm3
Boiling Point 1373ºC at 760mmHg
Molecular Formula C33H42N8O10S2
Molecular Weight 774.86400
Flash Point 784.2ºC
Exact Mass 774.24700
PSA 385.26000
LogP 1.92840
Index of Refraction 1.577
Storage condition 2-8℃

 Synthetic Route

 Synonyms

(7-de-L-proline)-[8-de-(amino acid)]-[9-de-(glycine amide)]-vasopressin
Pressinoic acid
pressinoic acid (disulfide)
L-cysteinyl->L-tyrosyl->L-phenylalanyl->L-glutaminyl->L-asparaginyl->L-cysteine [1]->[6]-disulfide
19-amino-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxylic acid
1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane,cyclic peptide deriv.
Oxytocin,3-L-phenylalanine-7-de-L-proline-8-de-L-leucine-9-deglycinamide
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