Trimazosin
Modify Date: 2024-01-06 20:52:59
Trimazosin structure
|
Common Name | Trimazosin | ||
|---|---|---|---|---|
| CAS Number | 35795-16-5 | Molecular Weight | 435.47 | |
| Density | 1.31g/cm3 | Boiling Point | 648.2ºC at 760mmHg | |
| Molecular Formula | C20H29N5O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 345.8ºC | |
Use of TrimazosinTrimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors[1][2]. |
| Name | (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate |
|---|---|
| Synonym | More Synonyms |
| Description | Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors[1][2]. |
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| Related Catalog | |
| Target |
α1-adrenergic receptor |
| In Vivo | Trimazosin (10–30 mg/kg; i.h.; once) produces graded decreases in blood pressure[3]. Animal Model: Conscious spontaneously hypertensive rats (SHR)[3] Dosage: 10–30 mg/kg Administration: Subcutaneous administration, once Result: Produced graded decreases in blood pressure. |
| References |
[2]. H L Elliott, et al. Trimazosin in normotensive subjects. Clin Pharmacol Ther. 1984 Feb;35(2):156-60. |
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 648.2ºC at 760mmHg |
| Molecular Formula | C20H29N5O6 |
| Molecular Weight | 435.47 |
| Flash Point | 345.8ºC |
| Exact Mass | 435.21200 |
| PSA | 132.50000 |
| LogP | 1.85140 |
| Index of Refraction | 1.606 |
| trimazosine |
| TRIMAZOSIN |
| EINECS 252-732-7 |