UNII:6LL60J9E0O
Modify Date: 2024-01-05 14:18:11
UNII:6LL60J9E0O structure
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Common Name | UNII:6LL60J9E0O | ||
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| CAS Number | 3614-69-5 | Molecular Weight | 408.490 | |
| Density | N/A | Boiling Point | 416.3ºC at 760mmHg | |
| Molecular Formula | C24H28N2O4 | Melting Point | 159-161℃ | |
| MSDS | N/A | Flash Point | 205.6ºC | |
Use of UNII:6LL60J9E0ODimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3]. |
| Name | (Z)-but-2-enedioic acid,N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine |
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| Synonym | More Synonyms |
| Description | Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2]. Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM[2]. |
| In Vivo | Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1]. Animal Model: C57BL/6 mice with wound healing[1] Dosage: 0.25 mg Administration: Intraperitoneal injection; 0.25 mg once Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing. |
| Boiling Point | 416.3ºC at 760mmHg |
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| Melting Point | 159-161℃ |
| Molecular Formula | C24H28N2O4 |
| Molecular Weight | 408.490 |
| Flash Point | 205.6ºC |
| Exact Mass | 408.204895 |
| PSA | 90.73000 |
| LogP | 3.85850 |
| Water Solubility | Slightly soluble in water, soluble in methanol |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xn |
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| HS Code | 2933399090 |
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Chiral separation of alkylamine antihistamines in pharmaceuticals by capillary isotachophoresis with charged cyclodextrin.
Drug Dev. Ind. Pharm. 33(11) , 1199-204, (2007) Cyclodextrin-mediated capillary isotachophoresis (ITP) in cationic regime of the separation was developed for the separation and quantitation of alkylamine antihistamine dimethindene (DIM) and phenira... |
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Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
Bioorg. Med. Chem. Lett. 20(19) , 5874-8, (2010) Analogs of the known H(1)-antihistamine R-dimethindene with suitable selectivity for key GPCRs, P450 enzymes and hERG channel were assessed for metabolism profile and in vivo properties. Several analo... |
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Identification and determination of ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method.
Acta Pol. Pharm. 70(6) , 951-9, (2013) Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals wer... |
| Fenistil-retard |
| N,N-Dimethyl-2-{3-[1-(2-pyridinyl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-2-butenedioate (1:1) |
| Fenistil |
| Forthistal maleate |
| 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (2Z)-2-butenedioate (1:1) |
| Dimethinden maleate |
| Forhistal maleate |
| Dimethpyrindene maleate |
| Dimethindene maleate |
| Dimetindene maleate |
| UNII:6LL60J9E0O |
| SU-6518 |
| 3-[a-(2'-Pyridyl)ethyl]-2-(b-dimethylaminoethyl)indene Maleate (1:1) |
| N,N-Dimethyl-2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethanamine (2Z)-but-2-enedioate (1:1) |
| dimetindene hydrogen maleate |