Kobusin
Modify Date: 2024-01-09 15:10:13
Kobusin structure
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Common Name | Kobusin | ||
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| CAS Number | 36150-23-9 | Molecular Weight | 370.39600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H22O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KobusinKobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2]. |
| Name | 5-[(3S,3aR,6S,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole |
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| Synonym | More Synonyms |
| Description | Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2]. |
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| Related Catalog | |
| In Vitro | Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells[1]. |
| In Vivo | In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice[1]. |
| References |
| Molecular Formula | C21H22O6 |
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| Molecular Weight | 370.39600 |
| Exact Mass | 370.14200 |
| PSA | 55.38000 |
| LogP | 3.50770 |
| Kobusin |