2,2'-Bipyridine

Modify Date: 2024-01-02 11:53:22

2,2'-Bipyridine Structure
2,2'-Bipyridine structure
 Common Name 2,2'-Bipyridine
CAS Number 366-18-7 Molecular Weight 156.184
Density 1.1±0.1 g/cm3 Boiling Point 272.5±0.0 °C at 760 mmHg
Molecular Formula C10H8N2 Melting Point 70-73 °C(lit.)
MSDS Chinese USA Flash Point 107.2±12.0 °C
Symbol GHS06
GHS06		 Signal Word Danger

 Use of 2,2'-Bipyridine


2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center[1].

 Names

Name 2,2'-bipyridine
Synonym More Synonyms

 2,2'-Bipyridine Biological Activity

Description 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center[1].
Related Catalog
References

[1]. Chen D, et al. Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era. J Ind Microbiol Biotechnol. 2019;46(3-4):459-468.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 272.5±0.0 °C at 760 mmHg
Melting Point 70-73 °C(lit.)
Molecular Formula C10H8N2
Molecular Weight 156.184
Flash Point 107.2±12.0 °C
Exact Mass 156.068741
PSA 25.78000
LogP 1.28
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.581
Stability Stable. Incompatible with strong oxidizing agents, most common metals. May be light sensitive.
Water Solubility 5.5 g/L 22 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DW1750000
CHEMICAL NAME :
2,2'-Bipyridine
CAS REGISTRY NUMBER :
366-18-7
BEILSTEIN REFERENCE NO. :
0113089
LAST UPDATED :
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C10-H8-N2
MOLECULAR WEIGHT :
156.20
WISWESSER LINE NOTATION :
T6NJ B- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes in urine composition Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
131 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8000 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
60 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
14500 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,223,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84441 No. of Facilities: 141 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84441 No. of Facilities: 461 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 3684 (estimated) No. of Female Employees: 886 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301 + H311
Precautionary Statements P280-P301 + P310-P312
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R25
Safety Phrases S36/37-S45-S36/37/39-S26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DW1750000
Packaging Group III
Hazard Class 6.1
HS Code 29333999

 Synthetic Route

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

bipyridine
2-(2-pyridyl)pyridine
α,α'-dipyridine
EINECS 206-674-4
2,2’-Bipyridyl
dipyridyl
2,2'-Bipyridin
2,2-BIPYRIDINE
2-pyridin-2-ylpyridine
2,2′-bipyridine
2,2′-bipyridyl
[2,2]Bipyridinyl
α,α'-bipyridine
2,2′ bipyridine
2,2’-bipyridine
2,2'-BIPYRIDINE-3,3'-DIOL
2,2'-Bipyridyl
2,2'-Bipyridine
2,2'-Dipyridyl
bipyridyl
bpy
2,2‘-Dipyridyl
2,2`-Bipyridyl
Dipyridyl, 2,2'
MFCD00006212
2,2′-bipyridinyl
2,2'-dipyridine
2,2-Dipyridyl
α,α'-dipyridyl
bipy
α,α'-Bipyridyl
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