Isorhamnetin 3-glucuronide

Modify Date: 2024-01-03 17:00:52

Isorhamnetin 3-glucuronide Structure
Isorhamnetin 3-glucuronide structure
Common Name Isorhamnetin 3-glucuronide
CAS Number 36687-76-0 Molecular Weight 492.38600
Density 1.83±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H20O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Isorhamnetin 3-glucuronide


Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase[1].

 Names

Name (2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonym More Synonyms

 Isorhamnetin 3-glucuronide Biological Activity

Description Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase[1].
Related Catalog
In Vitro Isorhamnetin 3-glucuronide (0-100 µM; 48 h) 以剂量依赖的方式对 MCF-7 细胞显示出抗增殖活性[1]。 Isorhamnetin 3-glucuronide (0-100 µM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 S 期[1]。 Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0, 25, 50, 100 µM Incubation Time: 48 h Result: Inhibited cell proliferation in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: MCF-7 cells Concentration: 25, 100 µM Incubation Time: 48 h Result: Induced apoptosis with the rate of 16.8%, 49.8% at 25, 100 µM, respectively. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 0, 50, 100 µM Incubation Time: 48 h Result: Induced cell cycle arrest at S-phase.
References

[1]. Wu Q, et al. Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. J Agric Food Chem. 2018 Jul 11;66(27):7181-7189.  

 Chemical & Physical Properties

Density 1.83±0.1 g/cm3
Molecular Formula C22H20O13
Molecular Weight 492.38600
Exact Mass 492.09000
PSA 216.58000
Water Solubility Very slightly soluble (0.36 g/L) (25 ºC)

 Synonyms

Isorhamnetin 3-glucuronide